Perturbed CD8(+) T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals

HIV-specific CD8(+) T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (ART). Expression levels of the inhibitory r...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tauriainen, Johanna, Scharf, Lydia, Frederiksen, Juliet, Naji, Ali, Ljunggren, Hans-Gustaf, Sönnerborg, Anders, Lund, Ole, Reyes-Terán, Gustavo, Hecht, Frederick M., Deeks, Steven G., Betts, Michael R., Buggert, Marcus, Karlsson, Annika C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233961/
https://ncbi.nlm.nih.gov/pubmed/28084312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40354
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