The N- and C-Terminal Domains of the NS1 Protein of Influenza B Virus Can Independently Inhibit IRF-3 and Beta Interferon Promoter Activation

The NS1 proteins of influenza A and B viruses (A/NS1 and B/NS1 proteins) have only ∼20% amino acid sequence identity. Nevertheless, these proteins show several functional similarities, such as their ability to bind to the same RNA targets and to inhibit the activation of protein kinase R in vitro. A...

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Autores principales: Donelan, Nicola R., Dauber, Bianca, Wang, Xiuyan, Basler, Christopher F., Wolff, Thorsten, García-Sastre, Adolfo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC523269/
https://ncbi.nlm.nih.gov/pubmed/15479798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.11574-11582.2004
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