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Low Level of Lytic Replication in a Recombinant Epstein-Barr Virus Carrying an Origin of Replication Devoid of BZLF1-Binding Sites

Binding of the BZLF1 viral transactivator to Epstein-Barr virus (EBV) oriLyt has been reported to be essential for viral DNA replication. We have constructed a recombinant virus (E2-oriLyt-R) in which the oriLyt BZLF1-binding sites (ZRE) were exchanged against papilloma E2-binding sites. A fusion pr...

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Bibliografische gegevens
Hoofdauteurs: Feederle, R., Delecluse, H. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2004
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC523260/
https://ncbi.nlm.nih.gov/pubmed/15479851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.12082-12084.2004
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