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The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development. However, power calculations are essential to obtain meaningful estimates of protective efficacy, while minimizing the risk of adverse events. To optimize p...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Coffeng, Luc E., Hermsen, Cornelus C., Sauerwein, Robert W., de Vlas, Sake J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5230743/
https://ncbi.nlm.nih.gov/pubmed/28081133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005255
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