A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

BACKGROUND: Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use o...

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Udgivet i:eLife
Main Authors: Reuling, Isaie J, van de Schans, Lisanne A, Coffeng, Luc E, Lanke, Kjerstin, Meerstein-Kessel, Lisette, Graumans, Wouter, van Gemert, Geert-Jan, Teelen, Karina, Siebelink-Stoter, Rianne, van de Vegte-Bolmer, Marga, de Mast, Quirijn, van der Ven, André J, Ivinson, Karen, Hermsen, Cornelus C, de Vlas, Sake, Bradley, John, Collins, Katharine A, Ockenhouse, Christian F, McCarthy, James, Sauerwein, Robert W, Bousema, Teun
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Microbiology and Infectious Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828662/
https://ncbi.nlm.nih.gov/pubmed/29482720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31549
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