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Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
Oxidative stress in cells can lead to accumulation of reactive oxygen species and oxidation of DNA precursors. Oxidized purine nucleotides can be inserted into DNA during replication and repair. The main pathway for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates D...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5228075/ https://ncbi.nlm.nih.gov/pubmed/28067232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14045 |
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