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Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure

Production of reactive oxygen and nitrogen species (ROS), such as hydrogen peroxide, superoxide and hydroxyl radicals, has been linked to cancer, and these oxidative molecules can damage DNA. Base excision repair (BER), a major repair system maintaining genome stability over a lifespan, has an impor...

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Bibliografske podrobnosti
izdano v:J Radiat Res
Main Authors: Çağlayan, Melike, Wilson, Samuel H
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737452/
https://ncbi.nlm.nih.gov/pubmed/28992331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrx027
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