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Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure

Production of reactive oxygen and nitrogen species (ROS), such as hydrogen peroxide, superoxide and hydroxyl radicals, has been linked to cancer, and these oxidative molecules can damage DNA. Base excision repair (BER), a major repair system maintaining genome stability over a lifespan, has an impor...

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Detalhes bibliográficos
Publicado no:J Radiat Res
Main Authors: Çağlayan, Melike, Wilson, Samuel H
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737452/
https://ncbi.nlm.nih.gov/pubmed/28992331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrx027
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