Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure

Production of reactive oxygen and nitrogen species (ROS), such as hydrogen peroxide, superoxide and hydroxyl radicals, has been linked to cancer, and these oxidative molecules can damage DNA. Base excision repair (BER), a major repair system maintaining genome stability over a lifespan, has an impor...

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Vydáno v:J Radiat Res
Hlavní autoři: Çağlayan, Melike, Wilson, Samuel H
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737452/
https://ncbi.nlm.nih.gov/pubmed/28992331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrx027
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