Polyphosphate Delays Fibrin Polymerisation and Alters the Mechanical Properties of the Fibrin Network

Polyphosphate (polyP) binds to fibrin(ogen) and alters fibrin structure, generating a heterogeneous network composed of ‘knots’ interspersed by large pores. Here we show platelet-derived polyP elicits similar structural changes in fibrin and examine the mechanism by which polyP alters fibrin structu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Thromb Haemost
Prif Awduron: Whyte, Claire S., Chernysh, Irina N., Domingues, Marco M., Connell, Simon, Weisel, John W., Ariens, Robert A. S., Mutch, Nicola J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Schattauer 2016
Pynciau:
Coagulation and Fibrinolysis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228039/
https://ncbi.nlm.nih.gov/pubmed/27610454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH16-01-0062
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