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The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
Ubiquitin-dependent degradation plays an important role in the negative regulation of TGF-β signaling. Here, we identify Tiul1 (for TGIF interacting ubiquitin ligase 1), a novel E3 ubiquitin ligase that inhibits TGF-β signaling by targeting both the activated receptor and Smad2 for degradation. Tiul...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522797/ https://ncbi.nlm.nih.gov/pubmed/15359284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600398 |
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