Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

Nonhomologous end joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammalian cells. A critical step in this process is DNA ligation, involving the Xrcc4–DNA ligase IV complex. DNA end processing is often a prerequisite for ligation, but the coordination of these events is...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Koch, Christine Anne, Agyei, Roger, Galicia, Sarah, Metalnikov, Pavel, O'Donnell, Paul, Starostine, Andrei, Weinfeld, Michael, Durocher, Daniel
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2004
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15385968/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600375
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