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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
Nonhomologous end joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammalian cells. A critical step in this process is DNA ligation, involving the Xrcc4–DNA ligase IV complex. DNA end processing is often a prerequisite for ligation, but the coordination of these events is...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
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Nature Publishing Group
2004
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522785/ https://ncbi.nlm.nih.gov/pubmed/15385968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600375 |
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