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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
Nonhomologous end joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammalian cells. A critical step in this process is DNA ligation, involving the Xrcc4–DNA ligase IV complex. DNA end processing is often a prerequisite for ligation, but the coordination of these events is...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522785/ https://ncbi.nlm.nih.gov/pubmed/15385968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600375 |
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