Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

The CRISPR–Cas9 system provides a versatile toolkit for genome engineering that can introduce various DNA lesions at specific genomic locations. However, a better understanding of the nature of these lesions and the repair pathways engaged is critical to realizing the full potential of this technolo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bothmer, Anne, Phadke, Tanushree, Barrera, Luis A., Margulies, Carrie M, Lee, Christina S., Buquicchio, Frank, Moss, Sean, Abdulkerim, Hayat S., Selleck, William, Jayaram, Hariharan, Myer, Vic E., Cotta-Ramusino, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5227551/
https://ncbi.nlm.nih.gov/pubmed/28067217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13905
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