c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether c-Src contributes to metabolic reprogramming. Here we find that c-Src can interact with and phosphorylate hexokinases HK1 and HK2, the rate-limiting enzymes in glycolysis. Tyrosine phosphorylation d...

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Udgivet i:Nat Commun
Main Authors: Zhang, Jia, Wang, Suili, Jiang, Bin, Huang, Lihong, Ji, Zhiliang, Li, Xiaotong, Zhou, Huamin, Han, Aidong, Chen, Ai, Wu, Yanan, Ma, Huanhuan, Zhao, Wentao, Zhao, Qingwen, Xie, Changchuan, Sun, Xiaoyan, Zhou, Yanming, Huang, Huiying, Suleman, Muhammad, Lin, Furong, Zhou, Lin, Tian, Fang, Jin, Meijun, Cai, Yana, Zhang, Nan, Li, Qinxi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5227066/
https://ncbi.nlm.nih.gov/pubmed/28054552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13732
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