IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53

Resistance to apoptosis and uncontrolled proliferation are two hallmarks of cancer cells. p53 is crucial for apoptosis triggered by a broad range of stresses and a well-known gatekeeper for neoplastic transformation. Here we show that oncogenic IDH1 R132H/R132Q mutants robustly inhibit p53 expressio...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Jiang, Bin, Zhao, Wentao, Shi, Minggang, Zhang, Jia, Chen, Ai, Ma, Huanhuan, Suleman, Muhammad, Lin, Furong, Zhou, Lin, Wang, Jinyang, Zhang, Yan, Liu, Mengjue, Wen, Shixiong, Ouyang, Cong, Wang, Huihui, Huang, Xiumin, Zhou, Huamin, Li, Qinxi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016470/
https://ncbi.nlm.nih.gov/pubmed/29743236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001385
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