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Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells

Platelet-derived growth factor (PDGF) plays an essential role in proliferation of vascular smooth muscle cells (VSMCs). The Rb/E2F and TSC/mTOR pathways contribute to the proliferation of VSMCs, but its exact roles in PDGF-induced proliferation are unclear. In this study, we demonstrated the roles o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Yue, Li, Xuan, Liu, Jie, Guo, Wei, Zhang, Hongchao, Wang, Jianchang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226788/
https://ncbi.nlm.nih.gov/pubmed/28076433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170036
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