Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling

Objective: Folic acid (FA) supplementation reduces the risk of atherosclerosis and stroke. Phenotypic change from differentiated to dedifferentiated vascular smooth muscle cells (VSMCs) plays an important role in atherosclerosis development; however, the exact mechanisms remain unknown. This study a...

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Veröffentlicht in:Am J Transl Res
Hauptverfasser: Pan, Sunlei, Lin, Hui, Luo, Hangqi, Gao, Feidan, Meng, Liping, Zhou, Changzuan, Jiang, Chengjian, Guo, Yan, Ji, Zheng, Chi, Jufang, Guo, Hangyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376021/
https://ncbi.nlm.nih.gov/pubmed/28386356
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