5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53

Recent findings revealed in cancer cells novel stress response pathways, which in response to many chemotherapeutic drugs causing nucleolar stress, will function independently from tumor protein p53 (p53) and still lead to cell cycle arrest and/or apoptosis. Since it is known that most cancers lack...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Pagliara, Valentina, Saide, Assunta, Mitidieri, Emma, Roberta d'Emmanuele di Villa, Bianca, Sorrentino, Raffaella, Russo, Giulia, Russo, Annapina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226586/
https://ncbi.nlm.nih.gov/pubmed/27385096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10385
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