Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis

Cancer stem cells are associated with tumor recurrence. IKK is a protein kinase that is composed of IKKα, IKKβ, IKKγ. Herein, we demonstrate that IKKα plus IKKβ promoted and IKKγ inhibited liver cancer stem cell growth in vitro and in vivo. Mechanistically, IKKα plus IKKβ enhanced and IKKγ inhibited...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: An, Jiahui, Wu, Mengying, Xin, Xiaoru, Lin, Zhuojia, Li, Xiaonan, Zheng, Qidi, Gui, Xin, Li, Tianming, Pu, Hu, Li, Haiyan, Lu, Dongdong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226573/
https://ncbi.nlm.nih.gov/pubmed/27367027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10321
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