Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer

Our previous study demonstrated that long non-coding RNA (lncRNA) BC087858 could stimulate acquired resistance to EGFR-TKIs in non-small cell lung (NSCLC) but the specific regulatory mechanism remained unknown. We aimed to explore the role and mechanism of lncRNA BC087858 on EGFR-TKIs acquired resis...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pan, Hui, Jiang, Tao, Cheng, Ningning, Wang, Qi, Ren, Shengxiang, Li, Xuefei, Zhao, Chao, Zhang, Limin, Cai, Weijing, Zhou, Caicun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226560/
https://ncbi.nlm.nih.gov/pubmed/27409677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10521
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