Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer

The aim of this study was to explore the role of long non-coding RNA UCA1 (urothelial cancer-associated 1) in acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). In our study, UCA1 expression was significan...

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Pubblicato in:Oncotarget
Autori principali: Cheng, Ningning, Cai, Weijing, Ren, Shengxiang, Li, Xuefei, Wang, Qi, Pan, Hui, Zhao, Mingchuan, Li, Jiayu, Zhang, Yishi, Zhao, Chao, Chen, Xiaoxia, Fei, Ke, Zhou, Caicun, Hirsch, Fred R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695138/
https://ncbi.nlm.nih.gov/pubmed/26160838
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