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Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion
Among ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC). Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH t...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5226516/ https://ncbi.nlm.nih.gov/pubmed/27384481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10354 |
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