Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

Glutaminase 1 (GLS1) expression is increased in non-small cell lung cancer (NSCLC). GLS1 knockdown using siRNA or inhibition using bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) induced cell cycle arrest with significant reduction of ATP level while levels of reactive oxygen sp...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Lee, Jae-Seon, Kang, Joon H, Lee, Seon-Hyeong, Hong, Dongwan, Son, Jaekyoung, Hong, Kyeong M, Song, Jaewhan, Kim, Soo-Youl
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261012/
https://ncbi.nlm.nih.gov/pubmed/27929535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.404
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