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UBL/BAG-domain co-chaperones cause cellular stress upon overexpression through constitutive activation of Hsf1

As a result of exposure to stress conditions, mutations, or defects during synthesis, cellular proteins are prone to misfold. To cope with such partially denatured proteins, cells mount a regulated transcriptional response involving the Hsf1 transcription factor, which drives the synthesis of molecu...

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Detalles Bibliográficos
Publicado en:Cell Stress Chaperones
Main Authors: Poulsen, Esben G., Kampmeyer, Caroline, Kriegenburg, Franziska, Johansen, Jens V., Hofmann, Kay, Holmberg, Christian, Hartmann-Petersen, Rasmus
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225068/
https://ncbi.nlm.nih.gov/pubmed/27966061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-016-0751-z
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