A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast

A mutation, L166P, in the cytosolic protein, PARK7/DJ-1, causes protein misfolding and is linked to Parkinson disease. Here, we identify the fission yeast protein Sdj1 as the orthologue of DJ-1 and calculate by in silico saturation mutagenesis the effects of point mutants on its structural stability...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Mathiassen, Søs G., Larsen, Ida B., Poulsen, Esben G., Madsen, Christian T., Papaleo, Elena, Lindorff-Larsen, Kresten, Kragelund, Birthe B., Nielsen, Michael L., Kriegenburg, Franziska, Hartmann-Petersen, Rasmus
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Protein Synthesis and Degradation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543670/
https://ncbi.nlm.nih.gov/pubmed/26152728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662312
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