Moderate endoplasmic reticulum stress activates a PERK and p38-dependent apoptosis

The endoplasmic reticulum (ER) has the ability to signal organelle dysfunction via a complex signaling network known as the unfolded protein response (UPR). In this work, hamster fibroblast cells exhibiting moderate levels of ER stress were compared to those exhibiting severe ER stress. Inhibition o...

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Bibliographic Details
Published in:Cell Stress Chaperones
Main Authors: Lumley, Emily C., Osborn, Acadia R., Scott, Jessica E., Scholl, Amanda G., Mercado, Vicki, McMahan, Young T., Coffman, Zachary G., Brewster, Jay L.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2016
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225058/
https://ncbi.nlm.nih.gov/pubmed/27761878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-016-0740-2
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