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Cutting Edge: Helminth coinfection blocks effector differentiation of CD8 T cells through alternate host Th2- and IL-10-mediated responses

Concurrent helminth infection potently inhibits T cell immunity; however, whether helminths prevent T cell priming or skew clonal recruitment and effector differentiation is not known. Using coinfection with two natural mouse pathogens, Heligsomosoides polygyrus and Toxoplasma gondii to investigate...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Marple, Andrew, Wu, Wenhui, Shah, Suhagi, Zhao, Yanlin, Du, Peicheng, Gause, William C., Yap, George S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225035/
https://ncbi.nlm.nih.gov/pubmed/27956529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601741
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