Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillation

BACKGROUND: Dabigatran etexilate is a prodrug whose absorption is opposed by intestinal P-glycoprotein and which is converted by carboxylesterase to its active form, dabigatran. Unlike other statins, simvastatin and lovastatin are potent inhibitors of P-glycoprotein and carboxylesterase, and might e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:CMAJ
Prif Awduron: Antoniou, Tony, Macdonald, Erin M., Yao, Zhan, Hollands, Simon, Gomes, Tara, Tadrous, Mina, Mamdani, Muhammad M., Juurlink, David N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Joule Inc. 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224945/
https://ncbi.nlm.nih.gov/pubmed/28246253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/cmaj.160303
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