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Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

Many pancreatic transcription factors that are essential for islet cell differentiation have been well characterized; however, because they are often expressed in several different cell populations, their functional hierarchy remains unclear. To parse out the spatiotemporal regulation of islet cell...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Churchill, Angela J, Gutiérrez, Giselle Dominguez, Singer, Ruth A, Lorberbaum, David S, Fischer, Kevin A, Sussel, Lori
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224921/
https://ncbi.nlm.nih.gov/pubmed/28071588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20010
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