Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X(7)-B motif

Hyaluronan synthases (HAS) normally make large (>MDa) hyaluronan (HA) products. Smaller HA fragments (e.g. 100–400 kDa) produced in vivo are associated with inflammation and cell signaling by HA receptors that bind small, but not large, HA. Although HA fragments can arise from breakdown by hyalur...

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Vydáno v:Glycobiology
Hlavní autoři: Baggenstoss, Bruce A, Harris, Edward N, Washburn, Jennifer L, Medina, Andria P, Nguyen, Long, Weigel, Paul H
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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Original articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224591/
https://ncbi.nlm.nih.gov/pubmed/27558839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww089
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