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Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X(7)-B motif

Hyaluronan synthases (HAS) normally make large (>MDa) hyaluronan (HA) products. Smaller HA fragments (e.g. 100–400 kDa) produced in vivo are associated with inflammation and cell signaling by HA receptors that bind small, but not large, HA. Although HA fragments can arise from breakdown by hyalur...

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Dettagli Bibliografici
Pubblicato in:Glycobiology
Autori principali: Baggenstoss, Bruce A, Harris, Edward N, Washburn, Jennifer L, Medina, Andria P, Nguyen, Long, Weigel, Paul H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224591/
https://ncbi.nlm.nih.gov/pubmed/27558839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww089
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