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Elucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomics

The identification of the modes of action of bioactive compounds is a major challenge in chemical systems biology of diseases. Genome-wide expression profiling of transcriptional responses to compound treatment for human cell lines is a promising unbiased approach for the mode-of-action analysis. He...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Iwata, Michio, Sawada, Ryusuke, Iwata, Hiroaki, Kotera, Masaaki, Yamanishi, Yoshihiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223214/
https://ncbi.nlm.nih.gov/pubmed/28071740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40164
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