Exploring the Mode of Action of Bioactive Compounds by Microfluidic Transcriptional Profiling in Mycobacteria

Most candidate anti-bacterials are identified on the basis of their whole cell anti-bacterial activity. A critical bottleneck in the early discovery of novel anti-bacterials is tracking the structure activity relationship (SAR) of the novel compounds synthesized during the hit to lead and lead optim...

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Autores principales: Murima, Paul, de Sessions, Paola Florez, Lim, Vivian, Naim, Ahmad Nazri Mohamed, Bifani, Pablo, Boshoff, Helena I. M., Sambandamurthy, Vasan K., Dick, Thomas, Hibberd, Martin L., Schreiber, Mark, Rao, Srinivasa P. S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729944/
https://ncbi.nlm.nih.gov/pubmed/23935951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069191
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