One-step (18)F labeling of biomolecules using organotrifluoroborates

Herein we present a general protocol for the functionalization of biomolecules with an organotrifluoroborate moiety so that they can be radiolabeled with aqueous (18)F fluoride ((18)F(−)) and used for positron emission tomography (PET) imaging. Among the β(+)-emitting radionuclides, fluorine-18 ((18...

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Udgivet i:Nat Protoc
Main Authors: Liu, Zhibo, Lin, Kuo-Shyan, Bénard, François, Pourghiasian, Maral, Kiesewetter, Dale O, Perrin, David M, Chen, Xiaoyuan
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223096/
https://ncbi.nlm.nih.gov/pubmed/26313478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2015.090
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