(18)F-click labeling of a bombesin antagonist with an alkyne-(18)F-ArBF(3) (-): in vivo PET imaging of tumors expressing the GRP-receptor

A clickable alkyne-modified arylborimidine is rapidly converted in 15 minutes to a highly polar (18)F-aryltrifluoroborate anion ((18)F-ArBF(3) (-)) at high specific activity. Following labeling, the alkyne-(18)F-ArBF(3) (-) was conjugated to the peptide bombesin (BBN) within 25 minutes in a second s...

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Detalhes bibliográficos
Main Authors: Li, Ying, Liu, Zhibo, Harwig, Curtis W, Pourghiasian, Maral, Lau, Joseph, Lin, Kuo-Shyan, Schaffer, Paul, Benard, Francois, Perrin, David M
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545365/
https://ncbi.nlm.nih.gov/pubmed/23342301
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