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One-Pot Two-Step Radiosynthesis of a New (18)F-Labeled Thiol Reactive Prosthetic Group and Its Conjugate for Insulinoma Imaging
[Image: see text] N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-6-fluoronicotinamide ([(18)F]FNEM), a novel prosthetic agent that is thiol-specific, was synthesized using a one-pot two-step strategy: (1) (18)F incorporation by a nucleophilic displacement of trimethylammonium substrate under mild...
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| Udgivet i: | Mol Pharm |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4224565/ https://ncbi.nlm.nih.gov/pubmed/24798315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp5001857 |
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