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Development of a new thiol site-specific prosthetic group and its conjugation with [cys(40)]-exendin-4 for in vivo targeting of insulinomas
A new tracer, N-5-[(18)F]fluoropentylmaleimide ([(18)F]FPenM), for site-specific labeling of free thiol group in proteins and peptides was developed. The tracer was synthesized in three steps ((18)F displacement of the aliphatic tosylate, di-Boc removal by TFA to expose free amine and incorporation...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779517/ https://ncbi.nlm.nih.gov/pubmed/23750453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc400084u |
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