Development of a new thiol site-specific prosthetic group and its conjugation with [cys(40)]-exendin-4 for in vivo targeting of insulinomas

A new tracer, N-5-[(18)F]fluoropentylmaleimide ([(18)F]FPenM), for site-specific labeling of free thiol group in proteins and peptides was developed. The tracer was synthesized in three steps ((18)F displacement of the aliphatic tosylate, di-Boc removal by TFA to expose free amine and incorporation...

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Bibliografiske detaljer
Main Authors: Yue, Xuyi, Kiesewetter, Dale O., Guo, Jinxia, Sun, Zhongchan, Zhang, Xiaoxiang, Zhu, Lei, Niu, Gang, Ma, Ying, Lang, Lixin, Chen, Xiaoyuan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779517/
https://ncbi.nlm.nih.gov/pubmed/23750453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc400084u
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