A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

The complexity of the tumor microenvironment is difficult to mimic in vitro, particularly regarding tumor–host interactions. To enable better assessment of cancer immunotherapy agents in vitro, we developed a three-dimensional (3D) heterotypic spheroid model composed of tumor cells, fibroblasts, and...

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Dettagli Bibliografici
Pubblicato in:Cancer Immunol Immunother
Autori principali: Herter, Sylvia, Morra, Laura, Schlenker, Ramona, Sulcova, Jitka, Fahrni, Linda, Waldhauer, Inja, Lehmann, Steffi, Reisländer, Timo, Agarkova, Irina, Kelm, Jens M., Klein, Christian, Umana, Pablo, Bacac, Marina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222939/
https://ncbi.nlm.nih.gov/pubmed/27858101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1927-1
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