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Effect of Age and Renal Function on Idarucizumab Pharmacokinetics and Idarucizumab-Mediated Reversal of Dabigatran Anticoagulant Activity in a Randomized, Double-Blind, Crossover Phase Ib Study
BACKGROUND AND OBJECTIVES: Idarucizumab is an antibody fragment that specifically reverses dabigatran-mediated anticoagulation. Safety, pharmacokinetics and pharmacodynamics of idarucizumab were investigated in dabigatran-treated, middle-aged, elderly and renally impaired volunteers with characteris...
Zapisane w:
Wydane w: | Clin Pharmacokinet |
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Główni autorzy: | , , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
Springer International Publishing
2016
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5222901/ https://ncbi.nlm.nih.gov/pubmed/27317414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0417-0 |
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