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Human Immunodeficiency Virus Type 1 Vpr-Mediated G(2) Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the event of irreparable damage, commitment to apoptosis. Under conditions of replication stress, the damag...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522272/ https://ncbi.nlm.nih.gov/pubmed/15485898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9286-9294.2004 |
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