HIV-1 Vpr activates the G(2 )checkpoint through manipulation of the ubiquitin proteasome system

HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G(2 )and induction of apoptosis. In the present study, we investigate the role of the ubiquitin/proteasome system (UPS) in the above activity of V...

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Bibliografiske detaljer
Main Authors: DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos MR, Argañaraz, Enrique R, Planelles, Vicente
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904188/
https://ncbi.nlm.nih.gov/pubmed/17559673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-57
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