Human Immunodeficiency Virus Type 1 Vpr-Mediated G(2) Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation

Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the event of irreparable damage, commitment to apoptosis. Under conditions of replication stress, the damag...

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Main Authors: Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, Choudhary, Shailesh K., Camerini, David, Nghiem, Paul, Planelles, Vicente
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC522272/
https://ncbi.nlm.nih.gov/pubmed/15485898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9286-9294.2004
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