Role of KEAP1/NRF2 and TP53 mutations in lung squamous cell carcinoma development and radiotherapy response prediction

Lung squamous cell carcinomas (LSCC) pathogenesis remains incompletely understood and biomarkers predicting treatment response remain lacking. Here we describe novel murine LSCC models driven by loss of Trp53 and Keap1, both of which are frequently mutated in human LSCCs. Homozygous inactivation of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Discov
Hlavní autoři: Jeong, Youngtae, Hoang, Ngoc T., Lovejoy, Alexander, Stehr, Henning, Newman, Aaron M., Gentles, Andrew J., Kong, William, Truong, Diana, Martin, Shanique, Chaudhuri, Aadel, Heiser, Diane, Zhou, Li, Say, Carmen, Carter, Justin N., Hiniker, Susan M., Loo, Billy W., West, Robert B., Beachy, Philip, Alizadeh, Ash A., Diehn, Maximilian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222718/
https://ncbi.nlm.nih.gov/pubmed/27663899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0127
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky