Role of KEAP1/NFE2L2 mutations in the chemotherapeutic response of non-small cell lung cancer patients

PURPOSE: Activation of NFE2L2 has been linked to chemoresistance in cell line models. Recently, somatic mutations which activate NFE2L2, including mutations in NFE2L2, KEAP1, or CUL3, have been found to be associated with poor outcomes in patients with non-small cell lung cancer (NSCLC). However, th...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Jeong, Youngtae, Hellyer, Jessica A., Stehr, Henning, Hoang, Ngoc T., Niu, Xiaomin, Das, Millie, Padda, Sukhmani K., Ramchandran, Kavitha, Neal, Joel W., Wakelee, Heather, Diehn, Maximilian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942632/
https://ncbi.nlm.nih.gov/pubmed/31548347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1237
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