Role of KEAP1/NRF2 and TP53 mutations in lung squamous cell carcinoma development and radiotherapy response prediction

Lung squamous cell carcinomas (LSCC) pathogenesis remains incompletely understood and biomarkers predicting treatment response remain lacking. Here we describe novel murine LSCC models driven by loss of Trp53 and Keap1, both of which are frequently mutated in human LSCCs. Homozygous inactivation of...

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Publicado no:Cancer Discov
Main Authors: Jeong, Youngtae, Hoang, Ngoc T., Lovejoy, Alexander, Stehr, Henning, Newman, Aaron M., Gentles, Andrew J., Kong, William, Truong, Diana, Martin, Shanique, Chaudhuri, Aadel, Heiser, Diane, Zhou, Li, Say, Carmen, Carter, Justin N., Hiniker, Susan M., Loo, Billy W., West, Robert B., Beachy, Philip, Alizadeh, Ash A., Diehn, Maximilian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222718/
https://ncbi.nlm.nih.gov/pubmed/27663899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0127
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