Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase

DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. However, the main kinds and sources of DNA damage repaired by HR in somatic cells and the roles of important HR proteins remain elusive. We present engineered proteins that trap,...

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Xia, Jun, Chen, Li-Tzu, Mei, Qian, Ma, Chien-Hui, Halliday, Jennifer A., Lin, Hsin-Yu, Magnan, David, Pribis, John P., Fitzgerald, Devon M., Hamilton, Holly M., Richters, Megan, Nehring, Ralf B., Shen, Xi, Li, Lei, Bates, David, Hastings, P. J., Herman, Christophe, Jayaram, Makkuni, Rosenberg, Susan M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2016
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222578/
https://ncbi.nlm.nih.gov/pubmed/28090586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601605
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