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Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Mucosal epithelial cells are uniquely equipped to maintain barrier function even under adverse conditions. Previous studies have implicated hypoxia in mucosal tissue damage resulting from both acute and chronic inflammation. Given the importance of the transcriptional regulator hypoxia-inducible fac...

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Main Authors: Karhausen, Jörn, Furuta, Glenn T., Tomaszewski, John E., Johnson, Randall S., Colgan, Sean P., Haase, Volker H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC522241/
https://ncbi.nlm.nih.gov/pubmed/15489957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421086
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