Tumor Necrosis Factor Alpha Induction of NF-κB Requires the Novel Coactivator SIMPL

A myriad of stimuli including proinflammatory cytokines, viruses, and chemical and mechanical insults activate a kinase complex composed of IκB kinase β (IKK-β), IKK-α, and IKK-γ/N, leading to changes in NF-κB-dependent gene expression. However, it is not clear how the NF-κB response is tailored to...

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Опубликовано в::	Mol Cell Biol
Главные авторы:	Kwon, Hyung-Joo, Breese, Erin Haag, Vig-Varga, Eva, Luo, Yong, Lee, Younghee, Goebl, Mark G., Harrington, Maureen A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 2004
Предметы:	Gene Expression
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15485901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.21.9317-9326.2004
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