Tumor Necrosis Factor Alpha Induction of NF-κB Requires the Novel Coactivator SIMPL

A myriad of stimuli including proinflammatory cytokines, viruses, and chemical and mechanical insults activate a kinase complex composed of IκB kinase β (IKK-β), IKK-α, and IKK-γ/N, leading to changes in NF-κB-dependent gene expression. However, it is not clear how the NF-κB response is tailored to...

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Detalhes bibliográficos
Main Authors: Kwon, Hyung-Joo, Breese, Erin Haag, Vig-Varga, Eva, Luo, Yong, Lee, Younghee, Goebl, Mark G., Harrington, Maureen A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522234/
https://ncbi.nlm.nih.gov/pubmed/15485901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9317-9326.2004
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